Fisetin

Product Details

Name: Fisetin

CAS: 528-48-3

Feature:

Fisetin, also known as urushiflavin, is a flavonoid and is considered to be a drug for aging, which means it can kill aging cells. According to rodent studies, it may reduce the number of senescent cells in tissues and prolong life span. Lutein is a flavonoid. It is hard to dissolve in water, carbon tetrachloride and petroleum ether. It is easily soluble in acetone and acetic acid. It is widely distributed in fruits and vegetables such as strawberry, apple, onion, cucumber and so on. It is widely distributed, cheap and easy to obtain, and has a wide range of pharmacological activities, such as anti-inflammatory, antioxidant, anticoagulant, antithrombotic, antispasmodic, and treatment of diabetic kidney injury.

Fisetin has the following applications/functions:

Inhibition of cardiac hypertrophy,anti-aging,Anti tumor

1.Fisetin can inhibit cardiac hypertrophy induced by pressure overload, improve cardiac function in vivo and inhibit cardiac hypertrophy induced by phenylephrine (PE) in vitro. In hypertrophic heart and cardiomyocytes, fisetin treatment significantly reduced the level of reactive oxygen species (ROS). In addition, fisetin significantly upregulated the expression of antioxidant genes, including catalase (CAT), superoxide dismutase 1 (SOD1) and heme oxygenase 1 (HO-1). In addition, the CO treatment of N-acetylcysteine (NAC, ROS scavenger) and fisetin had no synergistic inhibitory effect on PE induced cardiomyocyte hypertrophy, indicating that the anti hypertrophy effect of fisetin was mainly related to blocking oxidative stress. Finally, after pressure overload and PE treatment, we found that the signal pathway of hypertrophy, mitogen activated protein kinase (MAPK) and mammalian target of rapamycin (mTOR) kinase were inhibited by fisetin.

2.Fisetine can delay aging. Fisetine is an important nutritional supplement, which can improve cell viability, especially the viability of senescent cells. In this way, the metabolism, immunity, brain function and cardiovascular function of the human body will be improved. Therefore, it can improve the function of the human body as a whole, make all cells in the body in a new active state, eliminate diseases, and achieve the effect of delaying aging.

3.The anti-tumor mechanisms of fisetine include inhibition of cell proliferation, induction of apoptosis, intervention of signal transduction, influence of cell cycle and angiogenesis, etc., but it also plays an anti-tumor role in influencing tumor cell cycle.

Composition: 

Appearance: Yellow powder

Assay: 98%

Packing: 25kg/drum or as discussed

Shelf Life: 2 years

Storage: Store in cool and dry area

Certification:ISO GMP KOSHER HALAL