Agmatine sulfate is an aminoguanidine, also known as (4-aminobutyl) guanidine, and was originally discovered in 1910. It is created naturally from the amino acid, arginine, and plays a role in several different body functions including acting as a neuromodulator and neurotransmitter. It also plays an important role in nitric oxide synthesis, which may promote healthy circulation and muscle pump during exercise.
Agmatine Sulfate is a nootropic and bodybuilding supplement that is sometimes referred to as “Super Arginine”. It exerts many of the same effects as this compound, although there are also novel effects not observed with its parent compound.
Agmatine is a naturally-occurring biogenic amine that is derived from the conditionally essential amino acid L-Arginine. This occurs due to a process called decarboxylation, which is the removal of a carboxylic acid group from the amino acid.
Agmatine is purported to have mental (nootropic), physical and analgesic benefits. It appears to demonstrate many of the same effects as l-Arginine supplementation, but at a greater potency.
It is typically used as a pre-workout supplement by bodybuilders to improve “muscle pumps” and promote the growth of muscle tissue. It may help athletes achieve better body composition, improved stamina and reduced pain after a workout.
The supplement is also used to promote mental well-being and cognitive performance. According to anecdotal reports, it supports a healthy mood, has anti-anxiety properties, and may have synergistic benefits when stacked with Nootropic supplements like Aniracetam and other Ampakines.
The cognitive enhancement effects are believed to be mediated by the NMDA receptor, which plays a role in memory formation and synaptic plasticity.
Agmatine Sulfate also acts as an anti-oxidant and is being studied for pro-longevity effects. It has been found to exhibit neuroprotection against damage and injuries to the Central Nervous System (CNS). It is also believed to to limit the activity of glutamate receptors and thus, over-excitation of certain neurons in the brain.
Some individuals will take Agmantine Sulfate to prevent excitotoxicity which can occur when using too much Sunifiram, Unifiram, Modafinil or other similar nootropic supplements. Removal of free radicals, toxins, and other poisons can help to keep not only the brain but the entire body in a better state of health.
There are also a number of athletic effects related to sport nutrition. This includes enhancing and improving insulin response of the body. This has long been thought to be one of the keys to building a leaner, stronger, and more muscular body.
The supplement is additionally thought to stimulate the production and increase of GH (Growth Hormone) and LH (Luteinizing Hormone) which can have positive effects upon overall body composition and lean muscle tissue.
Like the amino acid l-Arginine, this supplement also acts as a Nitric Oxide (NO) booster and activates the enzyme Nitric Oxide Synthase (NOS). Due to the regulation of Nitric Oxide production in the body, Agmatine Sulfate may also lead to better muscle “pumps” in weight training athletes.
Muscle pumps refer to the sensation of increased blood filling up your muscles and causing them to swell. The pump is believed to improve nutrient delivery to your muscle cells, which may support growth and faster recovery.
Compared to L-arginine supplementation, Agmatine is believed to have better oral bioavailability and require a lower dosage to increase nitric oxide.
This supplement is also reported to act as an analgesic, which means that it may have a positive effect on the relief of pain. In one study, it was found to reduce pain, inflammation and tissue damage following spinal cord injury in rats.
Agmatine is observed to release several types of endorphins and natural opioid substances in the brain. It has also been used in conjunction with morphine and marijuana, having a synergistic effect. Some researchers feel that there may be therapeutic uses for Agmatine in helping to treat addictions.
This supplement may affect energy metabolism, though it is unclear what the practical result of this will be in humans. Bacteria studies show that it can be used to generate ATP (Adenosine Triphosphate), which is the energy molecule used within your cells.
Agmatine seems to be able to up-regulate or down-regulate polyamine accumulation in the cells. The enzyme agmatinase converts this compound into the polyamine putrescine, but it can also reduce polyamine activity through the protein antizyme.
Post time: Apr-29-2020