Cefotaxime sodium is a commonly used carbapenem antibiotic. It belongs to the third generation of semi-synthetic cephalosporins. It has a wider antibacterial spectrum than cefuroxime and has a stronger effect on Gram-negative bacteria. The antibacterial spectrum includes hemophilia Intestines such as influenza bacillus, E. coli, Escherichia coli, Salmonella Klebsiella and Proteus mirabilis, Neisseria, Staphylococcus, pneumococcus, streptococcus, Klebsiella and Salmonella Bacillus bacteria etc. Cefotaxime sodium has no antibacterial activity against Pseudomonas aeruginosa and Alcaligenes, has poor antibacterial activity against Staphylococcus aureus, and has strong activity against Gram-positive cocci such as hemolytic streptococcus and streptococcus pneumoniae. Enterococcus (Enterobacter cloacae, Enterobacter aerogenes) resistant to this product.
Cefotaxime is widely distributed in various tissues and body fluids throughout the body. The concentration of drugs in normal cerebrospinal fluid is very low; after applying this product in meningitis patients, the effective concentration in cerebrospinal fluid can be achieved. Bronchial secretions, middle ear discharge, pleural effusion, empyema, ascites, gallbladder wall, bile, and bone tissue can all reach effective concentrations: this product can enter the human fetal blood circulation through the placental barrier, a small amount can also Into the milk.
It is used for infection of respiratory tract, urinary tract, bones and joints, skin and soft tissue, abdominal cavity, bile tract, digestive tract, facial features, genitals and other parts caused by sensitive bacteria. It is also effective for infections caused by burns, trauma, sepsis and central infections.
Post time: May-07-2020