Ceramide is a kind of phospholipid with ceramide as the skeleton, mainly including ceramide choline phosphate and ceramide ethanolamine phosphate. Phospholipid is the main component of cell membrane. 40% ~ 50% of sebum in stratum corneum is composed of ceramide. Ceramide is the main part of intercellular matrix and plays an important role in maintaining the water balance of stratum corneum. At the same time, ceramide also has the effect of fighting tumor and inflammation for human body.
Ceramide used in skin can resist aging. Ceramide is the main component of skin cuticle lipid, which can help repair skin barrier and make skin soft and shiny. But ceramide decreases with age, and the skin becomes dark and dry without it. Timely supplement can improve the condition of dry, desquamate and rough skin; At the same time, ceramide can increase the thickness of epidermal stratum corneum, improve skin water holding capacity, reduce wrinkles, enhance skin elasticity and delay skin aging.
Ceramide can also regulate cell growth variation. It plays an important messenger role in the biological effects induced by a variety of cytokines, vitamin D3, Fas and CD28 ligands. Its role in mediating apoptosis has attracted more and more attention; At the same time, ceramide is also involved in many physiological and pathological processes such as cell differentiation. Ceramide can induce apoptosis in epidermal keratinocyte culture. Ceramide is the decomposition product of sphingomyelin in biofilm bilayer and is recognized as the second messenger.
Ceramide can prevent cardiovascular diseases. Ceramide plays a significant role in inducing endothelial cell apoptosis. It can be seen that ceramide plays a very important role in regulating endothelial cell integrity and endocrine function. Ceramide induces apoptosis of vascular endothelial cells through Fas pathway, which plays a very important role in studying the mechanism of ceramide induced apoptosis of vascular endothelial cells.
Post time: Aug-02-2021