Diclazuril is a triazine acetonitrile compound. It is a new, highly effective and low-toxic anticoccidial drug, which is widely used in chicken coccidiosis. The mechanism of diclazuril’s anticoccidial action is not yet clear. The main peak period of action on coccidia varies with different species of coccidia. For example, the main point of action on Eimeria tenella is the sexual cycle of the second generation of schizont coccidia. However, it is ineffective against the giant, Eimeria brucei schizonts. The action point on giant Eimeria is in the zygote stage of coccidia; it is highly effective on the small gametophyte stage of Eimeria brucei.
Diclazuril also has an inhibitory effect on the formation of sporulated oocysts. Diclazuril premix is a white or light yellow powder; almost odorless, it is slightly soluble in dimethylformamide, slightly soluble in tetrahydrofuran, and almost insoluble in water and ethanol. Insoluble in water limits its use.
This product is a broad-spectrum anticoccidial drug, has a coccidiosis effect, has an effect on all stages of coccidiosis development, and has low toxicity. It is currently an ideal drug against coccidiosis. The peak period of diclazuril’s main effect on coccidia varies with different species of coccidia, such as the main point of action on Eimeria tenella in the second generation of schizonts and the point of action on giant Eimeria In the zygote stage of coccidia, it is highly effective for the small gametophyte stage of Eimeria brucei. This product can also inhibit the formation of sporulated oocysts.
Diclazuril has excellent effects on chicken tenderness, pile type, poisoning, Brucella, giant Eimeria. In addition to the effective control of the occurrence of cecal coccidiosis and the death of chickens, it can even make sick chicken balls The oocysts all disappeared. Diclazuril is also effective for alleviating Eimeria. Diclazuril‘s control effect against coccidiosis is better than monensin, amphetamine, laxaloxin, nicarbazin, clopyridine and so on. The feed concentration of 1 mg/kg can effectively control duck coccidiosis, and its effect even exceeds polyether antibiotics. Diclazuril 1 mg/kg feed concentration can effectively prevent Eimeria glandularis, Eimeria turkey, Eimeria peacock and Eimeria dispersa infection. Feeding rabbits with 1 mg/kg feed is highly effective for rabbit liver coccidiosis and enterococci.
Post time: Jun-17-2020