Enrofloxacin and Sarafloxacin, Danofloxacin, Difloxacin, Ofloxacin, Norfloxacin, Orbifloxacin are currently the third generation of fluoroquinolone broad-spectrum antibacterial drugs commonly used in veterinary clinics , Is an ethyl compound of ciprofloxacin, also known as ethyl ciprofloxacin, ethyl ciprofloxacin, enfloperic acid, which is effective against gram-negative bacteria, gram-positive bacteria and mycoplasma. The antibacterial activity is significantly better than norfloxacin, and its effect on mycoplasma is stronger than tylosin and tamomycin. This product is easily absorbed by oral administration, intramuscular and subcutaneous injections, and is widely distributed in the body. Except for the central nervous system, the drug concentration in other tissues is almost higher than the blood drug concentration. It can be deethylated in the body and mainly produces the active metabolite ciprofloxacin, but the metabolic differences among animals are large. The metabolic rate in poultry, dogs, rabbits and cattle is high, and the metabolism in horses and pigs The rate is low. Clinical enrofloxacin is mainly used to treat various mycoplasmosis, Escherichia coli, Salmonella, Haemophilus, Erysipelas, Staphylococcus, Streptococcus and other respiratory system, digestive system, urogenital system infections, skin infections and Sepsis etc. Especially suitable for mixed infection caused by a variety of bacteria.
Enrofloxacin is less toxic and safe for clinical use. The therapeutic dose has no teratogenic and mutagenic effects. Can make the cartilage of young animals turbid, causing lameness and pain. Digestive system reactions include vomiting, abdominal pain, and bloating. Skin reactions include erythema, itching, urticaria and photosensitivity.
Precautions:
① The aqueous solution of Enrofloxacin is easily discolored and decomposed when exposed to light, and should be kept away from light.
② The drug-resistant strains of this product are increasing, and should not be used for a long time at sub-therapeutic doses.
③The antacid can inhibit the absorption of this product, and should avoid drinking it at the same time.
④During clinical application, the dosage can be adjusted according to the disease type, the concentration range of poultry drinking water, add 25-100 mg per liter of drinking water.
⑤The withdrawal period of chickens is 8 days. Laying hens are banned during the laying period.
⑥ Chicks are very sensitive to enrofloxacin injection. There have been many reports of poisoning in China, and the dosage should be strictly controlled.
Post time: Jun-17-2020