Maduramycin ammonium, also known as maduramycin ammonium, maduramycin. Maduramycin ammonium salt is a new type of polyether ionophore antibiotic developed by the American cyanamide company in the 1980s. It is produced by microbial fermentation and has a wide spectrum of anticoccidial. Eimer type, Eimbruch’s, slow-released Eimer, modified Eimer, and poisoned Eimeria have good results.
Maduramycin ammonium salt is a white crystalline powder with a melting point of 165-167 ° C. It is insoluble in water and soluble in organic solvents. Due to its broad anticoccidial spectrum and resistance to drug resistance, it is widely used, but its The dosage is very small. At present, our country stipulates that the amount of maduramycin ammonium salt used to prevent chicken coccidiosis is 5mg / kg. Maduramycin ammonium salt premix has extremely high requirements on product uniformity and stability. For example, the content of the product should be 95-110% of the marked amount, the content uniformity (coefficient of variation) is less than 3%, and the stability meets the standard Claim.
At present, the processing methods of maduramycin ammonium salt at home and abroad are roughly as follows: First, the maduramycin ammonium salt raw powder is directly mixed with the carrier to make a premix, which is added to the feed at the prescribed dose and mixed for use. The second is to dissolve the water-insoluble maduramycin ammonium salt in organic solvents such as ethyl acetate and benzyl alcohol, and then spray the solution evenly on the soybean meal or corncob carrier to form a premix after mixing and drying. Add to the feed for mixing according to the prescribed dosage; three is to first make the mixture of maduramycin powder and starch into granules, then mix it with the carrier to make a premix, and add to the feed for mixing according to the prescribed dosage; four It is an emulsion or liquid preparation made by dissolving maduramycin ammonium salt in an organic solvent.
Post time: May-27-2020