Nitroimidazole derivatives. It has strong antimicrobial activity against anaerobic bacteria, trichomonas, amoeba and Giardia lamblia. Used for: 1) Mixed infection of various aerobic bacteria and anaerobic bacteria, including abdominal and pelvic infections, lung abscess, brain abscess, etc., but usually combined with anti-aerobic bacteria antibacterial drugs. 2) Oral administration can be used for pseudomembranous enteritis caused by Clostridium difficile, Hp-related gastritis, periodontal infection and Gardnerella vaginitis, etc. It is the first choice for the treatment of vaginal trichomoniasis. 3) Treatment of intestinal and parenteral amoebiasis, vaginal trichomoniasis, dracunculiasis, giardiasis, and pouch trichomoniasis. 4) Combined with other antibacterial drugs, it can be used for the prevention of pelvic, intestinal and abdominal cavity operations.
Metronidazole is a nitroimidazole antibiotic, also known as metronidazole,and has a killing effect on anaerobic microorganisms. It is generated when it is reduced in the human body. The metabolites also have anti-anaerobic bacteria, inhibit the synthesis of bacterial deoxyribonucleic acid, thereby interfering with the growth and reproduction of bacteria, and eventually causing bacterial death. Anti-anaerobic bacteria include: Bacteroides fragilis and Clostridium (due to the sharp appearance of the bacteria Named fusiform), Tetanus, Peptococcus, Peptostreptococcus, Giardia. Initially used to treat vaginal trichomoniasis, the clinical effect is very significant. Later, it was discovered that metronidazole can also kill anaerobic bacteria that cause oral infections. In 1978, it was determined by the World Health Organization as a special drug against anaerobic infections. It was widely used to prevent and treat oral anaerobic infections. In the hospital, this product is also often used to prevent and treat respiratory tract, digestive tract, abdominal and pelvic infections caused by anaerobic bacteria, skin and soft tissue and bone and joint infections, pericarditis, sepsis and brain treatment. Metronidazole has a significant effect on amoebiasis in the body and intestinal cavity, and it is also the first choice for humans to treat worm diseases. The mechanism of action is by inhibiting the redox reaction of amebic protozoa, causing the protozoan nitrogen chain to break. effect. In vitro tests have shown that when the drug concentration is 1~2mg/L, the lytic tissue of amoeba can change its shape within 6~20 hours, and all of it can be killed within 24 hours. The concentration of 0.2mg/L can be killed within 72 hours. It is widely used in the treatment of intestinal and parenteral amoebiasis (such as amoebic liver abscess, pleural amoebic disease, etc.). Nitroimidazole antibiotics interact with ethanol, nicotine, etc., interfere with the oxidation process of ethanol, can cause disulfiram reaction, resulting in symptoms such as faster heart rate and lower blood pressure, so patients should avoid contact with alcoholic beverages while taking medicine , Smoking less to avoid adverse drug reactions.
Post time: Jun-23-2020