Rifampin is a broad-spectrum antibiotic and can enter the cell. It is a full-effect bactericidal agent with strong bactericidal power.

Rifampin is a broad-spectrum antibiotic drug belonging to the rifamycin family. It has a strong antibacterial effect on Mycobacterium tuberculosis, and it also has a therapeutic effect on Gram-positive or negative bacteria and viruses. Red or dark red crystalline powder, insoluble in water. It is usually taken as capsules or tablets for oral administration. It is synergistic with other anti-tuberculosis drugs and delays the production of drug-resistant strains.

Rifampin is a rifamycin-based semi-synthetic broad-spectrum antibacterial drug. Vancomycin can be used in combination with various pathogenic microorganisms to enhance the antibacterial activity. This medicine has obvious bactericidal effect on Mycobacterium tuberculosis and some non-tuberculous Mycobacteria (including Mycobacterium leprae, etc.) both inside and outside the host cell. Rifampin has a good antibacterial effect on aerobic Gram-positive bacteria, including staphylococcal enzyme-producing strains and methicillin-resistant strains, Streptococcus pneumoniae, other streptococcus species, Enterococcus species, Listeria spp. Capsular bacilli, diphtheria bacilli, anaerobic cocci etc.

It also has high antibacterial activity against aerobic gram-negative bacteria such as Neisseria meningitidis, Haemophilus influenzae, and Neisseria gonorrhoeae. Rifampin also has a good effect on Legionella, and has an inhibitory effect on pathogens such as Chlamydia trachomatis, lymphogranuloma venereum, and psittacosis. The bacteria are cross-resistant to rifamycin antibiotics. Rifampin firmly binds to the β subunit of DNA-dependent RNA polymerase, inhibits the synthesis of bacterial RNA, prevents the enzyme from connecting with DNA, thereby blocking the RNA transcription process and stopping the synthesis of DNA and protein

[Indications for Rifampin] Rifampin clinically mainly targets anaerobic bacteria such as Escherichia coli, Salmonella, Clostridium welchii, Mycoplasma, Chlamydia, etc. 1. Avian enteric syndrome, salpingitis, ovitis, peritonitis, chronic Respiratory diseases and other diseases; 2. Intractable enteritis, endometritis, dysentery, edema disease, streptococcus, asthma, pleural pneumonia, diarrhea and diarrhea caused by various diseases in pigs.