Sodium Camphor Sulfonate is an important intermediate for organic synthesis, optically active resolving agent. Due to its optical rotation, it can be used in the racemization of optical isomers in the industry, and it is also widely used as a pharmaceutical intermediate, such as the production of intestinal disorder inhibitors, HIV improvers, etc. Left and right camphorsulfonic acids are used as important resolving agents for optically active amino acid drugs, such as camphorsulfonic acid as a chiral ion pair reagent to separate phenylpropanol with -receptor blocking effect, cardiac inhibition, and local anesthesia Five substances: amine, metoprolol, propranolol, epinephrine, salbutamol and atenolol. Salinating camphorsulfonic acid or obtaining corresponding camphorsulfonate through other synthetic routes also has a wide range of uses. For example, sodium camphorsulfonate is a veterinary central stimulant that can stimulate the respiratory center and excite the breath for treatment. Acute disorder of breathing and circulation, against central nervous system poisoning, etc.; ammonium camphor sulfonate is added as a chiral ion pair reagent to the mobile phase to separate the enantiomers of aromatic alcohol amine drugs. At present, there are few domestic enterprises producing camphorsulfonic acid, basically relying on imports, the domestic market demand is large, the price of camphorsulfonic acid is also very expensive, especially L-camphorsulfonic acid. Natural camphor is mainly raised from camphor tree plants, ginger plants and alpinia seeds, and has optical activity; synthetic camphor generally isomerizes turpentine oil to obtain camphene, which is then eliminated by esterification, hydrolysis, dehydrogenation and other reaction processes. Rotation, almost no optical activity. At present, synthetic camphor is mainly used in daily chemical and light industries, and artificially separated natural camphor with optical activity is mainly used in the pharmaceutical industry. my country has natural resources of camphor powder, and the production of camphor sulfonic acid with camphor powder has greater economic and social benefits. Sodium camphorsulfonate is a respiratory stimulant with white crystals or crystalline powder. Odorless. The taste is slightly bitter at first, then sweet. Melting point is about 190°C. Easily soluble in water and hot ethanol. It has the exciting respiration and circulation of camphor. But not lasting. It is suitable for acute disorders of breathing and circulation, poisoning against central nervous system inhibitors, etc.
Post time: Jun-05-2020