Tiamulin is one of the ten veterinary antibiotics. Its antibacterial spectrum is similar to that of macrolide antibiotics. It is mainly resistant to Gram-positive bacteria. , Treponema pallidum dysentery, etc. have a strong inhibitory effect; the effect on mycoplasma is stronger than that of macrolides. Tiamulin is rapidly absorbed in animals, with high blood drug concentration, wide distribution in the body, and low residues. It is mainly used to prevent and treat chicken chronic respiratory disease, mycoplasma hyopneumoniae pneumonia, actinomycete pleuropneumonia and Treponema pallidum. When used in low doses, it can promote animal growth and increase feed utilization. The drug has been widely used around the world and has been recommended as the drug of choice for controlling Mycoplasma hyopneumoniae infection, with a large market demand.
【Drug Interaction】
① This product can affect the metabolism of polyether antibiotics such as monensin, salinomycin, etc. When used in combination, it can cause poisoning, slow growth of chickens, movement disorders, paralysis, and even death.
② This product is combined with antibiotics that can bind to the 50S subunit of bacterial ribosomes and has an antagonistic effect.
③ This product is mixed with chlortetracycline in a ratio of 1:4. It can treat swine bacterial enteritis, bacterial pneumonia, and Treponema pallidum. It can be mixed with Mycoplasma pneumonia, Bordetella bronchiseptica and Pasteurella multocida Pneumonia caused by infection is effective
Comparison of tiamulin and tylosin
The antibacterial effect of tiamulin is to inhibit the synthesis of susceptible proteins, that is, it acts on the ribosome in the bacterial body and binds to the bacterial ribosome 50S subunit to inhibit bacterial protein synthesis. Tymectin is tightly bound to the pocket protein domain of the peptide acyltransferase active center (PT C) in the 50S subunit of the cell, and its binding site is bound to the tRNAase substrate binding site (A site and P site ) Overlapping, thereby directly inhibiting the formation of bacterial protein peptide chains, mainly manifested as antibacterial effect, but it has a bactericidal effect at high concentrations.
The mechanism of action of tylosin is to inhibit bacterial protein synthesis. It binds to the 50s subunit of the ribosome, inhibits the binding of the aminoacyl end of aminoacyl tRNA-, and inhibits the complex of mRNA-aminoacyl-tRNA-ribosome Formation, different components have different binding ability to ribosomes. Tylosin tartrate has four components, ABCD, and its component A determines its active quality.
Tymectin and Tylosin both inhibit protein synthesis and have similar mechanisms of action, but different interference targets (one for peptidyl tRNA and one for aminoacyl tRNA), the two do not have cross-resistance, it is recommended to rotate the drug . Both Tiamulin and Tylosin are easily absorbed orally, and the peak blood concentration can be reached within 2-4 hours.
Post time: Jun-05-2020