Tretinoin
Name: Tretinoin
Feature:
Tretinoin is a metabolic intermediate product of vitamin A in the body, which mainly affects bone growth and epithelial metabolism, promotes epidermal cell proliferation, differentiation, keratolysis, and inhibits tumors. It is often used clinically for the treatment of skin diseases. From a traditional perspective, vitamin A has always been considered a vitamin, but in fact its role is similar to a hormone. But don’t panic, because A acid does not have the side effects of steroids and other hormones. Later, it was discovered that tretinoin can improve the acne and smooth the skin texture, improve the contour, and have a good anti-aging effect.
Tretinoin has the following applications/functions:
Antibacterial/anti-lipid/anti-aging, skin care products use its derivatives
1. Regulate the differentiation and proliferation of epidermal cells. Tretinoin can increase the DNA synthesis and mitosis index of epidermal cells by regulating the mitogen effect of epidermal growth factor, induce epidermal hyperplasia, and thicken the granular layer and the spinous cell layer. Another important role is to promote the differentiation of epidermal granular cells to the stratum corneum by influencing the K1 and K10 keratinase hydrolysis, the process of filaggrin to filaggrin and the formation of cross-linked envelope in the late stage of epidermal cell differentiation.
2. Affect the production of melanin. The action of tretinoin on melanocytes is multi-site, and it has inhibitory effect on the activities of three types of catalytic enzymes such as tyrosine hydroxylase, dopa oxidase and dihydroxyindole oxidase, thereby reducing the formation of melanin and reducing the skin. Pigmentation. It has no effect on normal melanocyte tyrosinase activity and melanin components.
3. Tretinoin can inhibit the secretion of sebaceous glands and make the maturation process of basal cells of sebaceous glands lengthen, reduce the number of sebaceous glands, and decrease the proportion of proliferating cells in the sebaceous glands, leading to the reduction of sebum synthesis.
4. Inhibit skin photoaging. Tretinoin can correct or prevent the abnormalities caused by harmful factors such as ultraviolet radiation to the biochemical composition and morphological structure of dermal connective tissue, stimulate the synthesis of skin extracellular matrix protein, and accelerate the formation of new connective tissue bands in the upper dermis.
Composition:
Appearance: Yellow powder
Assay: 98%
Packing: 25kg/drum
Shelf Life: 2 years
Storage: Store in cool and dry area
Certification:ISO GMP KOSHER HALAL
